Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization
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چکیده
منابع مشابه
Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior.
Chronic cocaine use reduces glutamate levels in the nucleus accumbens (NAc), and is associated with experience-dependent changes in (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) glutamate receptor membrane expression in NAc neurons. These changes accompany behavioral sensitization to cocaine and increased susceptibility to cocaine relapse. The functional relationship bet...
متن کاملThe persistence of behavioral sensitization to cocaine parallels enhanced inhibition of nucleus accumbens neurons.
The mesoaccumbens dopamine system is intricately involved in the locomotor stimulation produced by cocaine and sensitization of this effect following repeated cocaine administration. The mechanisms responsible for the expression of sensitized locomotion appear to involve alterations in both presynaptic (increased dopamine release) and postsynaptic (increased responsiveness of dopamine D1 recept...
متن کاملDopamine-Dependent Interactions between Limbic and Prefrontal Cortical Plasticity in the Nucleus Accumbens: Disruption by Cocaine Sensitization
The prefrontal cortex and the hippocampus exhibit converging projections to the nucleus accumbens and have functional reciprocal connections via indirect pathways. As a result, information processing between these structures is likely to be bidirectional. Using evoked potential measures, we examined the interactions of these inputs on synaptic plasticity within the accumbens. Our results show t...
متن کاملEnhanced inhibition of synaptic transmission by dopamine in the nucleus accumbens during behavioral sensitization to cocaine.
Neural adaptations in the nucleus accumbens (NAc), a key component of the mesolimbic dopamine (DA) system, are thought to mediate several of the long-term behavioral sequelas of chronic in vivo exposure to drugs of abuse. Here, we examine whether the modulation of excitatory synaptic transmission by DA in the NAc shell is modified after chronic cocaine exposure that induced behavioral sensitiza...
متن کاملNitric oxide mediation of morphine sensitization in the rat nucleus accumbens
Previous studies have reported that morphine exerts its effects in part through the release of nitric oxide (NO). It has been pustulated that drug sensitization is a major cause of relapse to drug use in addicts. In the present study the effects of intra-accumbal injections of L-arginine, the NO precursor and L-NAME, the NOS inhibitor on the morphine sensitization in Wistar rats (250-300 g) wer...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2009
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.2364